Thermo Fisher Scientific CD9 Monoclonal Antibody (eBioSN4 (SN4 C3-3A2)), PE, eBioscience
인간 CD9 항원을 인식하는 PE 결합 단클론 항체로, Flow Cytometry에 최적화되어 있습니다. 혈소판 및 면역세포 표지에 활용되며, 높은 특이성과 신뢰성 있는 신호를 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD9 Monoclonal Antibody (eBioSN4 (SN4 C3-3A2)), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution
- 5 µL (0.06 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioSN4 (SN4 C3-3A2) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10854122 |
Available Formats
- Unconjugated
- APC
- Biotin
- FITC
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 645
- Custom conjugation available
Product Specific Information
The eBioSN4 monoclonal antibody reacts with human CD9, a 24 kDa member of the tetraspanin family characterized by four hydrophobic transmembrane domains.
CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells, and neural cell lines. Its expression is associated with malignant phenotypes, including non-T cell acute lymphoblastic leukemia and chronic lymphocytic leukemia.
In platelets, CD9 is localized in alpha-granules and interacts with integrin αIIb/βIII to mediate platelet aggregation. CD9 also promotes pre-B cell aggregation, Schwann cell adhesion, and migration. It can provide a co-stimulatory signal for T cells independently of CD28.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human platelets.
Use at 5 µL (0.06 µg) per test in a final volume of 100 µL. Cell number may range from 10⁵ to 10⁸ cells/test.
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD9 antigen is a glycoprotein expressed on developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, neurons, and glial cells.
It belongs to the tetraspanin family, spanning the membrane four times. CD9 regulates cell activation and aggregation, possibly through association with integrin CD41/CD61 (GPIIb/GPIIIa).
CD9 plays roles in:
- Cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion
- Cell attachment and proliferation
- Association of MHC II molecules on dendritic cells for effective T cell stimulation
- Suppression of cancer cell motility and metastasis
CD9 is considered a metastasis suppressor in solid tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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