Thermo Fisher Scientific CD127 Polyclonal Antibody
CD127(IL7R) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트 시료에 반응하며, 고순도 Affinity chromatography 정제. PBS/glycerol buffer에 보관, -20°C에서 안정적 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL7R (Accession P16871), corresponding to amino acid residues N27–E47 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851804 |
Product Specific Information
Antibody detects endogenous levels of total IL7R.
Target Information
CD127 (Interleukin-7 receptor, IL7R) is a glycoprotein involved in the regulation of lymphopoiesis. The cellular response to CD127 depends on the presence of the IL7R complex, which functions as an alpha/gamma chain heterodimer. The gamma(c) chain is shared with the interleukin-2 receptor and primarily mediates signal transduction, while the alpha chain determines specific signaling events. CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. Dysfunction of CD127 is associated with severe combined immunodeficiency and related immune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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