Thermo Fisher Scientific Phospho-Myc (Ser373) Polyclonal Antibody
Phospho-Myc (Ser373) 폴리클로날 항체로, 인간, 마우스, 랫트 시료의 c-Myc 단백질 인산화 상태를 검출 가능. WB 및 IHC에 적합하며, Protein A로 정제된 고순도 항체. -20°C에서 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Dilution: 1:500–1:1,000
Immunohistochemistry (IHC)
- Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence including phosphorylation site of Serine 373 derived from human Myc and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is functionally associated with cell proliferation and regulation.
Studies indicate that c-Myc is essential for vasculogenesis and angiogenesis during tumor development. Deregulated expression of c-Myc can induce apoptosis and is implicated in numerous cancers including lung, breast, colon, and neuroblastomas.
Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci (chromosomes 14, 2, or 22) is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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