Thermo Fisher Scientific CMG2 Polyclonal Antibody
CMG2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 높은 순도와 재현성을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human CMG2 (amino acids 1–489, UniProt ID: P58335-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719741 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum by epitope-specific immunogen affinity chromatography. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Anthrax toxin receptor 2 (ATR2), also known as capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type I membrane protein containing an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. It binds to the protective antigen (PA) component of anthrax toxin, facilitating the entry of edema factor (EF) and lethal factor (LF) into the cytosol.
Mutations in ATR2/CMG2 can disrupt VWA domain binding and are associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), rare disorders characterized by hyaline deposition in skin and gingiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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