Thermo Fisher Scientific SIPA1L1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SIPA1L1. Recombinant protein control fragment (Product #RP-89050). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SIPA1L1,uniProtId:O43166-1,ncbiNodeId:9606,antigenRange:170-319,antigenLength:1804,antigenImageFileName:PA5-51761_SIPA1L1_O43166-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51761_SIPA1L1_O43166-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647311

Product Specific Information

Immunogen sequence: IRQRSNSDIT ISELDVDSFD ECISPTYKTG PSLHREYGST SSIDKQGTSG ESFFDLLKGY KDDKSDRGPT PTKLSDFLIT GGGKGSGFSL DVIDGPISQR ENLRLFKERE KPLKRRSKSE TGDSSIFRKL RNAKGEELGK SSDLEDNRSE

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.

Target Information

Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.