Thermo Fisher Scientific FBXO8 Polyclonal Antibody
Human FBXO8 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. IHC(P) 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관하며 연구용으로 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FBXO8. Recombinant protein control fragment (Product #RP-102198). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641558 |
Product Specific Information
Immunogen sequence:
WRVVRNQQLQ QEGYSEQGYL TREQSRRMAA SNISNTNHRK QVQGGIDIYH LLKARKSKEQ EGFINLEMLP PELSFTILSY LNATDLCLAS CVWQDLANDE LLWQGLCKST WGHCSIYNKN PPLGFSFRKL YMQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 92%
Target Information
This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. F-box proteins are subunits of the ubiquitin protein ligase complex SCFs (SKP1-cullin-F-box), functioning in phosphorylation-dependent ubiquitination.
They are divided into three classes:
- Fbws (WD-40 domains)
- Fbls (leucine-rich repeats)
- Fbxs (various or no recognizable motifs)
The FBXO8 protein belongs to the Fbxs class and contains a C-terminal sequence similar to yeast Sec7p, a regulator of vesicular protein transport. It may interact with ADP-ribosylation factors (ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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