Thermo Fisher Scientific GRP78 Polyclonal Antibody
GRP78 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. 인간 및 제브라피시 반응성. 단백질 접힘 및 스트레스 반응 연구에 적합. 4°C 또는 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Zebrafish |
| Published Species | Human, Zebrafish |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 261–289 amino acids from the central region of human HSPA5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542463 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, mouse, and rat based on sequence homology.
Target Information
GRP78 is a 78 kDa glucose-regulated protein belonging to the HSP70 family. It is an endoplasmic reticulum (ER) resident protein that associates with newly synthesized secretory and membrane proteins. GRP78 interacts with mutant and misfolded proteins, marking them for degradation. The conserved KDEL sequence at the C-terminus ensures recycling of ER proteins via the KDEL receptor.
GRP78 plays a key role in protein folding, degradation of misfolded proteins, and cell homeostasis. It is a biomarker for hypoglycemia and has neuroprotective functions under oxidative stress. Reduced GRP78 levels are observed in Alzheimer's disease and are associated with PS1 gene mutations. Induction of GRP78 has been linked to development of drug resistance in cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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