Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI1E1), TrueMAB

Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI1E1), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Transcriptional control is partly regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins). The conserved NAB proteins, NAB1 and NAB2, act as corepressors of EGF-1/NGFI-A.
Both NAB1 and NAB2 contain:

• N-terminal NAB conserved domain 1 (NCB1): required for binding NGFI-A
• C-terminal NCD2 domain: responsible for repressor function

NAB2 is primarily localized in the nucleus and is involved in downregulating NGFI-A activity, as well as regulating cell division, differentiation, and apoptosis.
It has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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