Thermo Fisher Scientific Human Ubiquilin 4 Synthetic Peptide
인간 Ubiquilin 4(CIP75) 아미노 말단 18개 잔기 서열 기반 합성 펩타이드. 항체 PA5-20781의 블로킹 펩타이드로 사용 가능. 단백질 분해 관련 연구용으로 적합. PBS(pH 7.2) 버퍼, 0.1% BSA 및 0.02% sodium azide 함유. -20°C 보관.
- 카탈로그번호
- PEP0895
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human CIP75.
PEP-0895 can be used as a blocking peptide with polyclonal antibody PA5-20781.
Target Information
The ubiquitin-proteasome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins.
The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain-containing protein family is thought to be involved in proteasomal degradation.
One such protein is CIP75, also known as ubiquilin-4, which interacts with proteins such as Ataxin-1 and Connexin-43, increasing their turnover rate.
Overexpression of CIP75 reduces Connexin-43 half-life, while siRNA knockdown has the opposite effect.
CIP75 contains an N-terminal UbL domain that interacts with the 26S proteasome complex and a C-terminal UBA domain that mediates interaction with Connexin-75.
At least three isoforms of CIP75 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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