Thermo Fisher Scientific Human Ubiquilin 4 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the amino terminus of human CIP75.
PEP-0895 can be used as a blocking peptide with polyclonal antibody PA5-20781.

Target Information

The ubiquitin-proteasome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins.
The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain-containing protein family is thought to be involved in proteasomal degradation.
One such protein is CIP75, also known as ubiquilin-4, which interacts with proteins such as Ataxin-1 and Connexin-43, increasing their turnover rate.
Overexpression of CIP75 reduces Connexin-43 half-life, while siRNA knockdown has the opposite effect.
CIP75 contains an N-terminal UbL domain that interacts with the 26S proteasome complex and a C-terminal UBA domain that mediates interaction with Connexin-75.
At least three isoforms of CIP75 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.