Thermo Fisher Scientific p53 Monoclonal Antibody (OTI1F4), TrueMAB
인간 p53 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot과 IHC(Paraffin)에 최적화됨. TrueMAB 형식으로 고순도 친화 크로마토그래피 정제. 세포 스트레스 반응 및 종양 억제 연구용에 적합.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F4 |
| Immunogen | Full length human recombinant protein of human TP53 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 regulates transcription of genes such as p21waf1 involved in G1 or G2/M arrest.
The structure includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is critical for activation and stabilization. p53 blocks proliferation of damaged cells and acts as an anticancer agent. Phosphorylation at Ser392 is associated with tumor formation. It is also linked to aging, oxidative stress, and cognitive function via LTP regulation.
Mutations in TP53 lead to loss of tumor suppressor activity and are common in human cancers. Germline mutations are found in cancer-prone families such as Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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