Thermo Fisher Scientific TOB2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-1 µg/mL

-

Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Horse, Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acids 50-100 of human TOB2 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TOB2,uniProtId:Q14106-1,ncbiNodeId:9606,antigenRange:50-100,antigenLength:344,antigenImageFileName:PA5-23289_TOB2_Q14106-1_Rabbit.svg,antigenImageFileNamePDP:PA5-23289_TOB2_Q14106-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540813

Target Information

TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.