Thermo Fisher Scientific c-Myc-tag Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute the lyophilized product with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

The c-Myc protein is a transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

A synthetic peptide corresponding to residues 410–419 of the human p62 c-Myc protein conjugated to KLH is used as the immunogen. The c-Myc-tag allows localization of gene products in diverse cell types, aiding in studies of protein topology, complex formation, and associated protein identification. This antibody is suitable for detecting expression levels of c-Myc fusion proteins or native c-Myc in multiple immunoassays.

Target Information

Myc is a proto-oncogene encoding a nuclear phosphoprotein involved in cell cycle progression, apoptosis, and cellular transformation. The protein forms a heterodimer with the transcription factor MAX, binding to the E-box DNA consensus sequence to regulate target gene transcription.

Gene amplification is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma. Translation may initiate from both an upstream non-AUG (CUG) and a downstream AUG start site, producing two isoforms with distinct N-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.