Thermo Fisher Scientific Phospho-p70 S6 Kinase (Thr421, Ser424) Recombinant Rabbit Monoclonal Antibody (HL129)
Phospho-p70 S6 Kinase (Thr421, Ser424) 특이성을 가진 Thermo Fisher Scientific의 HL129 재조합 토끼 단클론 항체. Western blot 검증 완료. 인간 및 마우스 반응성. 단백질 A 정제, PBS 용액 형태, 장기 보관 시 -20°C 권장.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL129 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human p70 S6K (phospho Thr421/Ser424). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890402 |
Product Specific Information
- Positive Control: 293T cells (starvation for 24 hr and incubated in 20% FBS for 0.5 hr)
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm and plays a key role in growth factor–regulated cell proliferation, motility, immune response, and tissue repair. It acts downstream of PI3-kinase, with its main physiological target being the S6 ribosomal protein, involved in upregulation of protein synthesis. Amplification and overexpression of p70 S6 kinase are observed in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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