Thermo Fisher Scientific H-Ras Polyclonal Antibody

Applications

• Western Blot (WB): 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Monomeric G protein Ras acts as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways leading to distinct cytoplasmic or nuclear events.
Mammalian cells contain three Ras proto-oncogenes encoding closely related Ras proteins: H-Ras, K-Ras, and N-Ras.
Oncogenic mutations in Ras genes occur in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression promotes proliferation and inhibits apoptosis.

• K-Ras mutations: Common in pancreatic, colorectal, and non-small-cell lung carcinomas
• H-Ras mutations: Common in bladder, kidney, and thyroid carcinomas
• N-Ras mutations: Found in melanoma, hematological malignancies, and hepatocellular carcinoma

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.