Thermo Fisher Scientific H-Ras Polyclonal Antibody
H-Ras 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 재구성 후 500 µg/mL 농도로 사용 가능합니다.
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Applications
- Western Blot (WB): 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human GTPase HRAS (111–137aa, MVLVGNKCDLAARTVESRQAQDLARSY) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2746511 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Monomeric G protein Ras acts as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways leading to distinct cytoplasmic or nuclear events.
Mammalian cells contain three Ras proto-oncogenes encoding closely related Ras proteins: H-Ras, K-Ras, and N-Ras.
Oncogenic mutations in Ras genes occur in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression promotes proliferation and inhibits apoptosis.
- K-Ras mutations: Common in pancreatic, colorectal, and non-small-cell lung carcinomas
- H-Ras mutations: Common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: Found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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