Thermo Fisher Scientific Sarcomeric Actinin Alpha 2/ACTN2 Monoclonal Antibody (ACTN2/3291)
ACTN2 단백질을 인식하는 Mouse monoclonal 항체로, 인간 시료에 반응합니다. IHC(P), IHC(PFA), Peptide Array에 사용 가능하며, 단백질 A/G로 정제된 액상 형태입니다. 보존제 없이 PBS(pH 7.4)에 보관하며, -20°C에서 냉동 보관 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ACTN2/3291 |
| Immunogen | Recombinant fragment (aa 557–692) of human ACTN2 protein (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha actinins belong to the spectrin gene superfamily, a diverse group of cytoskeletal proteins including alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types.
In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
In skeletal, cardiac, and smooth muscle, alpha actinin isoforms are localized to the Z-disc and dense bodies, anchoring the myofibrillar actin filaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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