Thermo Fisher Scientific ATG4B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

• Positive Samples: HepG2, BT-474, SKOV3, HeLa, Jurkat
• Cellular Location: Cytoplasm

Immunogen Sequence:
MDAATLTYDT LRFAEFEDFP ETSEPVWILG RKYSIFTEKD EILSDVASRL WFTYRKNFPA IGGTGPTSDT GWGCMLRCGQ MIFAQALVCR HLGRDWRWTQ RKRQPDSYFS VLNAFIDRKD SYYSIHQIAQ MGVGEGKSIG QWYGPNTVAQ VLKKLAVFDT WSSLAVHIAM DNTVVMEEIR RLCRTSVPCA GATAFPADSD RHCNGFPAGA EVTNRPSPWR PLVLLIPLRL GLTDINEAYV ETLKHCFMMP QSLGVIGGKP NSAHYFIGYV GEELIYLDPH TTQPAVEPTD GCFIPDESFH CQHPPCRMSI AELDPSIAVG FFCKTEDDFN DWCQQVKKLS LLGGALPMFE LVELQPSHLA CPDVLNLSLD SSDVERLERF FDSEDEDFEI LSL

Target Information

Cysteine protease ATG4B is an enzyme encoded by the ATG4B gene. Autophagy is a critical cellular homeostatic process controlling the turnover of damaged organelles and proteins. ATG4B acts as a deubiquitin-like protease with dual roles in autophagy machinery. It cleaves the C-terminal amino acid of ATG8 family proteins (MAP1LC3, GABARAPL1, GABARAPL2, GABARAP) to expose a C-terminal glycine, essential for conjugation to phosphatidylethanolamine (PE) and membrane insertion. ATG4B is mainly expressed in skeletal muscle, brain, heart, liver, and pancreas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)