Thermo Fisher Scientific CEA Monoclonal Antibody (1105)
CEA 단클론 항체(1105)는 인간 CEA(CD66e, CEACAM5)를 인식하는 Mouse IgG1 형 항체로, WB, ICC/IF, Flow, ELISA 등 다양한 분석에 적합합니다. Protein A로 정제된 액상 형태이며, 안정적인 장기 보관이 가능합니다.
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- MIC0101
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Thermo Fisher Scientific CEA Monoclonal Antibody (1105)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL | 2 publications |
| Flow Cytometry (Flow) | 5–20 µg/mL | 1 publication |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Radioimmune Assays (RIA) | Assay-dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1105 |
| Immunogen | Purified CEA from pooled tumors (Target: CD66e/CEACAM5, UniProt ID: P06731-1, Antigen length: 702 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.63 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152698 |
Product Specific Information
- Predicted molecular weight (MW) of CEA: ~77 kDa.
By Western blot, MIC0101 detects CEA with varying glycosylation at ~77–180 kDa. - Formerly sold as a Seradyn product.
- Material stability:
- 6 months at 2–8°C
- Up to 4 years at -20°C
Target Information
CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors.
It belongs to the immunoglobulin supergene family, consisting of a single N domain and six immunoglobulin constant-like domains (A1–A3, B1–B3).
Antibodies to CEA help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely CEA+).
CEA functions as a cell adhesion molecule detected on leukocytes, epithelia, and endothelia, involved in tissue structure, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants exist, though not all are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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