Thermo Fisher Scientific ERCC2 Monoclonal Antibody (OTI4B11), TrueMAB
ERCC2(XPD) 단백질을 인식하는 Mouse IgG2a 단일클론 항체. Western blot에 최적화되어 있으며, 인간 시료에 반응. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. DNA 손상 복구 연구에 적합.
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Thermo Fisher Scientific ERCC2 Monoclonal Antibody (OTI4B11), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 78–307 of human ERCC2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
XPD (ERCC2) is a key component of the nucleotide excision repair pathway responsible for repairing DNA damage. It functions in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex.
This ATP-dependent DNA helicase belongs to the RAD3/XPD subfamily of helicases. Mutations in this gene are associated with xeroderma pigmentosum (complementation group D), trichothiodystrophy, and Cockayne syndrome.
Alternative splicing produces multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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