Thermo Fisher Scientific CD127 Chimeric Recombinant Rat Monoclonal Antibody (YIL7R323)
인간 CD127(IL-7 수용체) 인식용 키메라 재조합 랫트 단클론 항체. Flow Cytometry 및 ELISA에 적합. HEK293 세포에서 발현, IgG2a 아이소타입. Protein A로 정제된 1 mg/mL 액상 형태. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | YIL7R323 |
| Immunogen | Proprietary sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3074438 |
Product Specific Information
Specificity: This antibody binds to an epitope of human Interleukin 7 receptor.
Target Information
CD127 (Interleukin-7 receptor, IL-7R) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 depends on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer.
CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, mainly activates signal transduction by the IL7R complex, while the alpha chain determines specific signaling events through its association with cytoplasmic signaling molecules.
CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor.
Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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