Thermo Fisher Scientific CD44 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: HeLa
• Predicted reactivity: Mouse (87%), Rat (88%), Dog (93%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.

CD44 functions as a receptor for hyaluronic acid (HA) and plays a key role in:

• Cell-cell interactions
• Cell adhesion and migration
• Lymphocyte activation, recirculation, and homing

CD44 expression can be upregulated in certain carcinomas and may be associated with metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia of cultured keratinocytes. Bone marrow myeloid cells and memory T cells express high levels of CD44, and peripheral B and T cells can upregulate CD44 expression upon stimulation.

Alternative splicing of the CD44 gene produces multiple isoforms with distinct structural and functional properties. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be related to tumor metastasis formation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.