
Thermo Fisher Scientific GCLC Polyclonal Antibody
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Applications
Tested Dilution
Publications
Western Blot (WB)
0.04-0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
1:50-1:200
Immunocytochemistry (ICC/IF)
0.25-2 µg/mL
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GCLC. Recombinant protein control fragment (Product #RP-94586). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
GCLC,
uniProtId:
P48506-1,
ncbiNodeId:
9606,
antigenRange:
436-536,
antigenLength:
637,
antigenImageFileName:
PA5-83330_GCLC_P48506-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-83330_GCLC_P48506-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2790486
Product Specific Information
Immunogen sequence: FENSAYVVFV VLLTRVILSY KLDFLIPLSK VDENMKVAQK RDAVLQGMFY FRKDICKGGN AVVDGCGKAQ NSTELAAEEY TLMSIDTIIN GKEGVFPGLI P
Target Information
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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