Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI3A5), TrueMAB
ITFG2 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot 검증 완료. 인간 시료 반응성, 비결합형 형태로 제공. mTORC1 신호 조절 연구에 적합하며, 고순도 친화 크로마토그래피 정제 제품.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A5 |
| Immunogen | Full length human recombinant protein of human ITFG2 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using the carrier-free antibody, perform an additional round of desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ITFG2 is part of the KICSTOR complex, functioning in the amino acid-sensing branch of the TORC1 signaling pathway.
It recruits the GATOR1 complex to lysosomal membranes, enabling its interaction with GATOR2 and RAG GTPases.
ITFG2 functions upstream of RAG GTPases, negatively regulating mTORC1 signaling in the absence of amino acids.
Without the KICSTOR complex, mTORC1 remains constitutively localized to the lysosome and activated.
The complex may also be involved in glucose-dependent regulation of mTORC1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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