Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI3A5), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using the carrier-free antibody, perform an additional round of desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ITFG2 is part of the KICSTOR complex, functioning in the amino acid-sensing branch of the TORC1 signaling pathway.
It recruits the GATOR1 complex to lysosomal membranes, enabling its interaction with GATOR2 and RAG GTPases.
ITFG2 functions upstream of RAG GTPases, negatively regulating mTORC1 signaling in the absence of amino acids.
Without the KICSTOR complex, mTORC1 remains constitutively localized to the lysosome and activated.
The complex may also be involved in glucose-dependent regulation of mTORC1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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