Thermo Fisher Scientific CCR4 Polyclonal Antibody
CCR4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 적용 가능. 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용.
- 카탈로그번호
- PA599885
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CCR4 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: [참고 문헌 링크]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [참고 문헌 링크]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CCR4 (Accession P51679), corresponding to amino acid residues M1–L48 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818818 |
Product Specific Information
Antibody detects endogenous levels of total CCR4.
Target Information
CCR4 is a chemokine receptor preferentially expressed on type 2 helper T (Th2-type) cells. Its expression, along with CCR8, is transiently increased following TCR and CD28 engagement. Activated Th1 cells also up-regulate CCR4 expression and responsiveness to thymus- and activation-regulated chemokine.
Chemokines are small (approximately 8–14 kD), mostly basic molecules that regulate leukocyte trafficking via 7-transmembrane, G protein-coupled receptors. They play essential roles in immune system development, homeostasis, and function, and also affect CNS and endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into two major subfamilies, CXC and CC, based on cysteine residue arrangements: adjacent cysteines in CC chemokines and one amino acid separation in CXC chemokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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