Thermo Fisher Scientific ZMYM2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive control: human ESC
• Predicted reactivity: Mouse (95%), Rhesus Monkey (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ZNF198 is a ubiquitously expressed nuclear protein with largely unknown physiological roles. It consists of five N-terminal zinc finger motifs for protein–protein interactions, a central proline-rich domain, and a C-terminal nuclear localization signal (NLS) with an acidic domain.
Chromosomal translocation involving ZNF198 and FGFR1 leads to the ZNF198/FGFR1 fusion kinase, a constitutively active cytoplasmic tyrosine kinase regulating STAT transcription factors (STAT1, STAT3, STAT5). This oncogenic fusion protein is associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.