Thermo Fisher Scientific ZMYM2 Polyclonal Antibody
ZMYM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능하며, Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 856–1336 of Human ZNF198 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545741 |
Product Specific Information
- Recommended positive control: human ESC
- Predicted reactivity: Mouse (95%), Rhesus Monkey (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ZNF198 is a ubiquitously expressed nuclear protein with largely unknown physiological roles. It consists of five N-terminal zinc finger motifs for protein–protein interactions, a central proline-rich domain, and a C-terminal nuclear localization signal (NLS) with an acidic domain.
Chromosomal translocation involving ZNF198 and FGFR1 leads to the ZNF198/FGFR1 fusion kinase, a constitutively active cytoplasmic tyrosine kinase regulating STAT transcription factors (STAT1, STAT3, STAT5). This oncogenic fusion protein is associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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