Thermo Fisher Scientific DNA-PK Recombinant Rabbit Monoclonal Antibody (23GB2055)
DNA-PK를 인식하는 토끼 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 인간 시료 반응성. HEK293F 발현 시스템에서 생산된 재조합 항체로 높은 특이성과 재현성 제공. 연구용으로만 사용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2055 |
| Immunogen | A synthesized peptide derived from human DNA-PKcs (4050–4128AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice (domestic); Dry ice (international) |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and is often inhibited by small molecules targeting these kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex essential for the expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting pre-initiation complex formation. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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