Thermo Fisher Scientific MERTK Recombinant Rabbit Monoclonal Antibody (23GB2070)
인간 MERTK 단백질을 표적으로 하는 재조합 토끼 단일클론 항체입니다. Western blot, ICC/IF, Flow cytometry 등 다양한 응용에 적합합니다. HEK293F 발현 시스템 기반으로 정제되었으며 PBS/glycerol 용액 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2070 |
| Immunogen | A synthesized peptide derived from human MERTK (25–48AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease.
It regulates many physiological processes including cell survival, migration, differentiation, and efferocytosis (phagocytosis of apoptotic cells).
Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain, providing docking sites for downstream signaling molecules.
Following activation, MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1.
MERTK signaling contributes to macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment.
In RPE, it functions as a regulator of rod outer segment fragment phagocytosis and plays a key role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response via STAT1 activation, leading to induction of SOCS1 and SOCS3.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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