Thermo Fisher Scientific TGFBR1 Polyclonal Antibody
TGFBR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에서 반응합니다. Western blot과 IHC(P) 적용 가능하며, 높은 특이성과 안정성을 제공합니다. 항원 친화 크로마토그래피로 정제된 액상 형태로 연구용에 적합합니다.
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- 판매단위
- pk
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Thermo Fisher Scientific TGFBR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Obtained from depletion column of three Non-Phosphospecific peptides (IYDM-T-T-SGS; DMTT-S-G-S-G-S-GLPL; EEDP-S-LDRPFI) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: MCF7
- Cellular location: Membrane, cytoplasm
Target Information
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-β, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation, leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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