Thermo Fisher Scientific TNFRSF14 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal TNFRSF14 항체. Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, PBS와 20% 글리세롤 용액에 보관. HSV 진입 및 면역 반응 연구에 활용 가능.
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- PA529780
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 60–283 of Human TNFRSF14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547254 |
Product Specific Information
- Recommended positive controls: A431, Molt-4, mouse spleen
- Predicted reactivity: Rhesus Monkey (82%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily and acts as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV envelope glycoprotein D (gD) to TNFRSF14 facilitates viral entry. The cytoplasmic region interacts with TRAF family members, mediating signal transduction pathways that activate immune responses. In T cells, TNFRSF14 activation promotes proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity. Multiple alternatively spliced transcript variants exist, though not all full-length forms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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