Thermo Fisher Scientific TERT Polyclonal Antibody
Human, Mouse, Rat 반응성의 Rabbit Polyclonal Anti-TERT 항체로 다양한 응용(WB, IHC, ICC, Flow, ELISA)에 사용 가능. KLH 결합 합성 펩타이드(aa 601–750)로 면역생성. 고순도 Protein A 정제, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific TERT Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TERT, amino acids 601–750 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by the TERT gene, and an RNA component serving as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells leading to progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may contribute to oncogenesis. Mouse studies suggest telomerase may also participate in chromosomal repair, as de novo synthesis of telomere repeats can occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; not all full-length sequences are determined. Alternative splicing at this locus is thought to regulate telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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