Thermo Fisher Scientific Phospho-DNA-PK (Ser2612) Polyclonal Antibody
DNA-PK 단백질의 Ser2612 인산화 부위를 인식하는 폴리클로날 항체입니다. Rabbit IgG로 제작되었으며, IHC(P)에서 1:50~1:100 희석 비율로 사용 가능합니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human DNA-PK around phosphorylation site Ser160 (Q-A-SP-Q-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555076 |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules designed for PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex essential for gene expression. This complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting pre-initiation complex formation. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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