Thermo Fisher Scientific GABRA6/GABA A Receptor alpha 6 Polyclonal Antibody
GABRA6/GABA A Receptor alpha 6에 특이적인 Thermo Fisher Scientific 폴리클로날 항체입니다. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, Rabbit IgG로 제작되었습니다. 단백질 A 정제 및 고순도 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GABRA6/GABA A Receptor alpha 6 (amino acids 85–180) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing membrane hyperpolarization through the opening of a Cl⁻ channel associated with the GABA-A Receptor (GABA-A R) subtype. GABA-A Rs are crucial therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABA-A R is a multimeric subunit complex with six alpha, four beta, and four gamma subunits identified, along with splice variants. Expression of alpha and beta subunits results in functional GABA-A Rs sensitive to GABA, while coexpression of a gamma subunit is required for benzodiazepine modulation. Benzodiazepine effects in the brain may be mediated by different alpha subunits, and phosphorylation of beta subunits can modulate receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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