Thermo Fisher Scientific ASCL1 Polyclonal Antibody
ASCL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human과 Mouse 시료에 반응. Western blot에 최적화된 항체로 신경계 발달 및 신경내분비 종양 연구에 활용 가능. 장기 보관 시 -20°C에서 안정적 유지.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 166–196 amino acids from the C-terminal region of human ASCL1 (Achaete-scute homolog 1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2059484 |
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early development of the nervous system. It is expressed in fetal brain and essential for the proper development and survival of autonomic neurons. ASCL1 interacts with MEF-2A to regulate gene expression critical for neuronal circuit formation. High ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer and small cell lung cancer, may serve as a marker for cancers with neuroendocrine features. The ASCL1 gene maps to human chromosome 12 and contains a trinucleotide repeat region, making it a candidate for inherited disease studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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