Thermo Fisher Scientific SGOL1 Polyclonal Antibody
SGOL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SGO1 (Accession Q5FBB7), corresponding to amino acid residues M1–S38 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903332 |
Product Specific Information
Antibody detects endogenous levels of total SGOL1.
Target Information
The SGOL1 gene encodes a member of the shugoshin family of proteins, which protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests protection of cohesin along chromosome arms and involvement in centriole cohesion via an isoform lacking exon 6. Mutations are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO). Fibroblast cells from CAID patients show increased proliferation and senescence. Pseudogenes exist on chromosomes 1 and 7. Multiple transcript variants occur due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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