Thermo Fisher Scientific PHIP Polyclonal Antibody
PHIP 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간 및 생쥐 반응성을 가지며, 고순도 친화 크로마토그래피로 정제되어 연구용으로 안정적인 결과를 제공합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1542–1821 of human PHIP (NP_060404.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.18 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855516 |
Product Specific Information
Immunogen sequence:
KTILENSVKH SKALNTLSSP GQSSFSHGTR NNSAKENMEK EKPVKRKMKS SVLPKASTLS KSSAVIEQGD CKNNALVPGT IQVNGHGGQP SKLVKRGPGR KPKVEVNTNS GEIIHKKRGR KPKKLQYAKP EDLEQNNVHP IRDEVLPSST CNFLSETNNV KEDLLQKKNR GGRKPKRKMK TQKLDADLLV PASVKVLRRS NRKKIDDPID EEEEFEELKG SEPHMRTRNQ GRRTAFYNED DSEEEQRQLL FEDTSLTFGT SSRGRVRKLT EKAKANLIGW
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP interacts with members of the insulin receptor substrate (IRS) family, which mediate insulin receptor signaling and play a key role in beta cell proliferation and survival. PHIP may function to link IRS-1 to insulin receptors, indicating a vital role in insulin signaling regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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