Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4169)
FGF23 단백질을 인식하는 Mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC(P), Peptide Array, Immunoelectrophoresis 등 다양한 응용에 사용 가능하며, 안정성과 특이성이 우수합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4169)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FGF23/4169 |
| Immunogen | Recombinant fragment (around aa25–251) of human FGF23 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human kidney tissue
- Cellular Localization: Secreted (extracellular)
- Specificity Comments:
Fibroblast growth factor-1 (FGF-1) and fibroblast growth factor-2 (FGF-2) are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial, and neuroectodermal origin.
Additional members of the FGF family include FGF-3 through FGF-23. Members share 30–55% amino acid sequence identity and similar gene structures, capable of transforming cultured cells when overexpressed.
Cellular receptors for FGFs are tyrosine kinases including FGFR-1 (Flg), FGFR-2 (Bek), TKF, and FGFR-3.
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion.
FGF23 inhibits renal tubular phosphate transport and is associated with autosomal dominant hypophosphatemic rickets and oncogenic hypophosphatemic osteomalacia. Mutations can cause familial tumoral calcinosis with hyperphosphatemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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