Thermo Fisher Scientific PTEN Recombinant Rabbit Monoclonal Antibody (SJ19-03)
PTEN 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot, IHC, ICC/IF 등에 사용 가능하며 인간, 마우스, 랫트 반응성을 가집니다. 고순도 Protein A 정제, 액상 형태로 1 mg/mL 농도이며 종양 억제 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SJ19-03 |
| Immunogen | Recombinant full length protein of human PTEN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093930 |
Product Specific Information
- Sequence Similarities: 99% Mouse / 98% Rat
- Tissue Specificity: Expressed at high levels in adult tissues including heart, brain, placenta, lung, liver, muscle, kidney, and pancreas
- Positive Control: MCF7, A431, HeLa, NIH/3T3, C6, PC-12 cell lysates; mouse and rat brain tissues
- Subcellular Location: Cytoplasm, Nucleus, Secreted
- Predicted Band Size: 47 kDa
Target Information
PTEN is a tumor suppressor frequently mutated in various cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase with tensin-like and catalytic domains. Unlike typical protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates, negatively regulating intracellular phosphatidylinositol-3,4,5-trisphosphate levels and the AKT/PKB signaling pathway. PTEN modulates AKT-mTOR signaling, influencing neuron integration, positioning, dendritic development, and synapse formation in adult neurogenesis. It may also negatively regulate insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form has greater apoptotic potential, while the cytoplasmic nonubiquitinated form shows reduced tumor suppressive ability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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