Thermo Fisher Scientific HDAC3 Monoclonal Antibody (B2-G9)
HDAC3 단백질을 인식하는 Mouse monoclonal 항체로 Western blot, IHC, ICC, Flow cytometry에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 affinity chromatography 정제 항체입니다. 세포 내 HDAC3 위치 및 발현 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B2-G9 |
| Immunogen | Synthetic peptide within C-terminal human HDAC3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911719 |
Product Specific Information
- Positive Control: MCF-7 lysate, PC-12 cell lysate, MCF-7, human kidney tissue, mouse kidney tissue, Hela
- Subcellular Location: Cytosol, Nucleus, Cytoplasm
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in transcription regulation through binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function, modulating cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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