Thermo Fisher Scientific Phospho-STAT3 (Ser727) Polyclonal Antibody
STAT3 단백질의 Ser727 인산화를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로, 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunoprecipitation (IP) | 2–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding the epitope -PMSPR- with phosphorylation at Ser727 of STAT3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: EGF-stimulated A431
- Cellular location: Nuclear
Target Information
STAT3 (Signal Transducer and Activator of Transcription 3) is a transcription factor activated by receptor-associated kinases in response to cytokines and growth factors. Upon phosphorylation, STAT3 translocates to the nucleus and regulates gene expression related to cell growth and apoptosis.
It is activated by IFN-α, EGF, PDGF, and IL-6, and phosphorylation at Tyr705 is essential for its dimerization and DNA binding. STAT3 interacts with coactivators such as CREB-binding protein and transcription factors like c-Jun and CREB.
In humans, the STAT3 gene is located on chromosome 17q, and multiple spliced variants exist. STAT3 knockout in mice is embryonically lethal, highlighting its essential role in development and cellular regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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