Thermo Fisher Scientific CD206 (MMR) Monoclonal Antibody (1E12A7)
CD206(MMR) 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. Western blot, ICC/IF, Flow Cytometry에 사용 가능하며, Protein G로 정제된 액상 형태입니다. 면역 관련 연구 및 CD206 발현 분석에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E12A7 |
| Immunogen | Purified recombinant fragment of human CD206 (AA: extra(19–218)) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090790 |
Target Information
CD206 (also known as MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the pattern recognition receptor family.
It is mainly expressed in tissue macrophages, dendritic cells, certain endothelial cells, and sperm cells. CD206 plays a key role in both innate and adaptive immune responses.
It mediates recognition and uptake of various macromolecules such as modified lipoproteins, advanced glycation end products (AGEs), and amyloid β-protein (Aβ).
While normally involved in cell adhesion and host defense, CD206 has also been implicated in atherosclerosis and amyloid β deposition in Alzheimer’s disease.
The CD206 gene encodes class A macrophage scavenger receptors with three isoforms (1, 2, 3) generated by alternative splicing.
- Isoforms 1 and 2 are functional and mediate endocytosis of modified LDLs.
- Isoform 3 lacks this function and remains trapped in the endoplasmic reticulum, exerting a dominant negative effect on the other isoforms.
Dysfunction of CD206 has been associated with diseases such as leprosy and Gaucher’s disease.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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