Thermo Fisher Scientific GLRB Polyclonal Antibody
GLRB 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 적합합니다. 인체, 마우스, 랫트에 반응하며, 고순도 친화 크로마토그래피 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GLRB (Accession P48167), corresponding to amino acid residues D210–F260 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851044 |
Product Specific Information
Antibody detects endogenous levels of total GLRB.
Target Information
In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutyric acid, serotonin, and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels.
The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins (alpha1 through alpha4 and beta) and an associated peripheral membrane protein, forming a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca²⁺ in the brainstem and midbrain indicates an important role for Ca²⁺ in modulation of glycinergic synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-101610_GLRB_P48167-1_Rabbit.svg, PA5-101610_GLRB_P48167-1_Rabbit_PDP.jpeg)
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