Thermo Fisher Scientific ERAS Polyclonal Antibody
ERAS 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 면역세포염색에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERAS (Accession Q7Z444), corresponding to amino acid residues H197–A233 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851050 |
Product Specific Information
Antibody detects endogenous levels of total ERAS.
Target Information
The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was later described as potentially encoding a functional human ERAS protein.
The ERAS oncogene supports tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein.
Although ERAS protein shares less than 50% amino acid identity with H-Ras, the key domains essential for Ras function are highly conserved.
The protein also contains amino acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells.
The human ERAS gene is localized in the chromosomal region Xp11.23.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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