Thermo Fisher Scientific DKK1 Polyclonal Antibody
DKK1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, ICC, Flow Cytometry 등에 사용 가능. 인간에 반응하며, 염소 유래 IgG 형식. Wnt/β-catenin 신호 억제 연구에 적합. 연구용으로만 사용.
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids CDHHQASNSSRLHT (aa 250–262) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2091327 |
Product Specific Information
- Predicted to react with bovine, canine, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
DKK-1 is a member of the DKK protein family, which includes DKK-2, DKK-3, and DKK-4.
Originally identified as a Xenopus head-forming molecule, DKK-1 acts as an antagonist of Wnt signaling.
DKK-1 and DKK-4 regulate the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, essential co-receptors for Wnt ligands.
By inhibiting Wnt/β-catenin signaling, DKK-1 facilitates anterior development in vertebrates.
Mice deficient in DKK-1 expression lack head formation and die during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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