Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI1B1), TrueMAB
ESR1(Estrogen Receptor alpha)을 인식하는 마우스 단일클론 항체로, Western blot 및 IHC(P) 검증 완료. HEK293T 세포에서 발현된 full-length 인간 단백질을 면역원으로 사용. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Full length human recombinant protein of human ESR1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors.
The estrogen receptor functions as a ligand-activated transcription factor that, upon binding to estrogen, undergoes conformational changes enabling dimerization and DNA binding at estrogen response elements (EREs).
ER regulates gene transcription by recruiting coactivator or corepressor proteins.
Two forms exist — ER alpha (ESR1) and ER beta (ESR2) — encoded by separate genes.
At least four isoforms of ER alpha are known (66, 53, 47, and 35 kDa).
ERs are broadly expressed and play essential roles in sexual development, reproduction, bone maintenance, and are implicated in diseases such as breast and endometrial cancers, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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