Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2)
CD42b 단백질을 인식하는 마우스 모노클로날 항체로, 인간 혈소판 및 거핵세포에서 발현되는 GPIbα를 타깃함. WB, ICC/IF, Flow Cytometry 등 다양한 실험에 사용 가능. 비결합형 항체이며 1 mg/mL 농도로 제공. 연구용으로만 사용.
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- MA543997
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK2 |
| Immunogen | Human platelets |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912929 |
Available Conjugated Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD42b (GPIb alpha), a 135–145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) form a disulfide-linked heterodimer (CD42b/c; 160 kDa), which associates noncovalently with CD42a and CD42d.
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF. Together with GPIb beta, GPIX, and GPV, CD42b forms the GPIb-IX-V receptor complex essential for platelet-rich thrombus formation. It binds von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. The extracellular domain contributes to metastasis. CD42b is expressed on platelets and megakaryocytes in bone marrow. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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