Thermo Fisher Scientific Laminin gamma-1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total LAMC1.

Target Information

Laminins are essential and abundant structural non-collagenous glycoproteins localized to basement membranes. These membranes are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen, and several proteoglycans. They are found under epithelial layers, around blood vessel endothelium, and surrounding muscle, peripheral nerve, and fat cells.
Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each Laminin is a heterotrimer of alpha, beta, and gamma chain subunits that undergo cell secretion and incorporation into the extracellular matrix (ECM).
Laminins can self-assemble, bind to other matrix macromolecules, and interact with cells via Integrins, dystroglycan, and Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.