Thermo Fisher Scientific CUEDC2 Monoclonal Antibody (OTI2H6), TrueMAB
Human CUEDC2 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 적합. Affinity chromatography로 정제된 Lyophilized 형태이며, PBS buffer에 trehalose 포함. 재구성 후 1 mg/mL 농도로 사용 가능하며, 단백질 상호작용 연구에 활용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H6 |
| Immunogen | Full-length human recombinant CUEDC2 protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using the carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain mediating intramolecular monoubiquitylation.
CUE domains are found in eukaryotic proteins involved in ubiquitination and protein trafficking.
CUEDC2 interacts with the progesterone receptor (PR) to promote PR degradation via the ubiquitin-proteasome pathway and decreases PR sumoylation.
It also interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by inhibiting IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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