Thermo Fisher Scientific COPS7A Polyclonal Antibody
COPS7A 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 사람, 생쥐, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제. 액상 형태로 안정적이며 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific COPS7A Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human COPS7A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553932 |
Product Specific Information
This antibody detects endogenous COPS7A protein at a molecular weight of approximately 30 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The COP9 signalosome (CSN) complex is involved in various developmental and cellular processes.
It consists of multiple subunits: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b), and CSN8 (COP8).
The CSN complex regulates the ubiquitin conjugation pathway by mediating deneddylation of SCF-type E3 ligase complexes, decreasing their ubiquitin ligase activity.
It also participates in phosphorylation processes involving p53, c-Jun, IκB-alpha, and IRF-8.
CSN7 is phosphorylated by CK2 and consists of two subunits (a and b).
CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region and a coiled-coil region, predicted to interact with CSN2–CSN8 and GPS1.
CSN7b contains only a PCI region and is predicted to interact with INT6.
Notice
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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