Thermo Fisher Scientific DOCK11 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

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Immunoprecipitation (IP)

-

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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to residues in human DOCK11

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2553933

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 238 kDa.

Purity is >95% by SDS-PAGE.

Target Information

Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell-cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.