Thermo Fisher Scientific DOCK11 Polyclonal Antibody
DOCK11 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 Immunoprecipitation에 사용 가능. 사람, 생쥐, 랫드에 반응하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%), 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human DOCK11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553933 |
Product Specific Information
- Detects endogenous DOCK11 protein at a molecular weight of approximately 238 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Small GTPases of the Rho family (Rho, Rac, and Cdc42) are essential regulators of the actin cytoskeleton and various cellular processes.
Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs).
DOCK11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073-amino-acid protein belonging to the DOCK family of cytokinesis-regulating proteins, primarily expressed in peripheral blood leukocytes.
DOCK11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP.
Cdc42 mediates cell polarity, gene expression, cell cycle progression, and cell-cell contacts.
Similar to other DOCK family members, DOCK11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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