Thermo Fisher Scientific p70 S6 Kinase Monoclonal Antibody (05)
인간 PS6K/RPS6KB1 단백질을 인식하는 p70 S6 Kinase 단클론 항체입니다. ELISA에 적합하며, 보존제가 포함되지 않은 액상 형태로 제공됩니다. 단백질 A로 정제되었으며, 단기 4℃ 보관 및 장기 -20℃ 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 05 |
| Immunogen | Recombinant Human PS6K/RPS6KB1 protein (Met1–Leu525) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786800 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human PS6K/RPS6KB1.
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein.
p70 S6 kinase is predominantly localized in the cytoplasm and is essential in growth factor–regulated cell proliferation, pathways involving cell motility (such as metastasis), the immune response, and tissue repair.
It acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in the upregulation of protein synthesis.
The kinase activity of p70 S6 kinase leads to increased protein synthesis and cell proliferation. Amplification and overexpression of p70 S6 kinase are observed in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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