Thermo Fisher Scientific KCNE1 Polyclonal Antibody
KCNE1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC에 적합합니다. 합성 펩타이드를 면역원으로 사용하였으며, 인간 시료에 반응합니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human KCNE1 (Potassium voltage-gated channel subfamily E member 1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: KCNE1.
Target Information
Kcne1 is a member of the voltage-gated potassium (Kv) channel family, which plays a key role in various physiological processes such as neurotransmitter release, heart rate regulation, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume control.
The Kcne1 gene encodes a membrane protein similar to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1 is an intronless gene deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities associated with this condition. Functionally, Kcne1 acts as a potassium channel ancillary subunit essential for generating native K(+) currents by forming heteromeric ion channel complexes with Kv channel pore-forming alpha subunits. It also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.
Diseases associated with KCNE1 include Jervell and Lange-Nielsen Syndrome 2 and Long QT Syndrome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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