Thermo Fisher Scientific KCNE1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: KCNE1.

Target Information

Kcne1 is a member of the voltage-gated potassium (Kv) channel family, which plays a key role in various physiological processes such as neurotransmitter release, heart rate regulation, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume control.
The Kcne1 gene encodes a membrane protein similar to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1 is an intronless gene deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities associated with this condition. Functionally, Kcne1 acts as a potassium channel ancillary subunit essential for generating native K(+) currents by forming heteromeric ion channel complexes with Kv channel pore-forming alpha subunits. It also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.
Diseases associated with KCNE1 include Jervell and Lange-Nielsen Syndrome 2 and Long QT Syndrome 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.